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[8] Tchang, B.G., et al

Moreover, although the surface of HGF II-K1 for c-MET binding is exposed, the binding of another c-MET to HGF II-K1 in such rigid conformation would clash with HGF I bound c-MET II on the stalk region, explaining why rigid HGF II in the 2:2 complex cannot recruit additional c-MET molecule