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[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Satarug S., Gobe G.C., Vesey D.A

Consistent with an induction of oxidative stress condition, metformin increased mRNA levels of the master redox transcription factor Nrf-2 (nuclear factor erythroid-derived 2-like), as well as transsulfuration enzymes cystathionine beta-synthase and cystathionase and GSH synthesis enzymes -glutamylcysteine synthetase and glutathione synthetase

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however, this therapeutic effect is abolished following vagotomy, indicating that the gut microbiotas influence on behavior is mediated via vagal signaling (Sgritta et al., 2019)

Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx