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Krlovec K, et al

Subcutaneous injection can cause local soreness, redness, or itching that disrupts sleep

Chronic stress, synapse loss, and depression Brain-derived neurotrophic factor (BDNF) is a crucial extracellular signaling protein belonging to the neurotrophin family, which supports neuronal development, survival, and plasticity (111)

The intestinal barrier may, therefore, be a target for therapeutic approaches to alter the course and mitigate the complications associated with a disruption in its functions