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This practice has continued despite significant controversy in the field as a result of two high profile Mayo Clinic trials carried out in the late 1970s which debunked the initially encouraging findings of Moertel et al., 1985)

Additionally, insulin resistance was measured using the homeostatic assessment model (HOMA-IR), and was defined as fasting plasma glucose x fasting serum insulin [2]

Cancer 54, 1832

These observations have stimulated growing interest in antioxidant-based approaches as potential preventive or therapeutic strategies in PE, although their clinical effectiveness remains under active investigation

Again, some 2HG could be seen, in keeping with an IDH-mutant lesion