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10.1016/0003-4975(93)91016-G 23

Nebbioso M, Fameli V, Gharbiya M, Sacchetti M, Zicari AM, Lambiase A

Environmental factors associated with IBD pathogenesis include stress, smoking, unhealthy lifestyle, and poor hygiene, whereas the use of non-steroid anti-inflammatory drugs, antibiotics, or appendectomy has also been associated with IBDs [36]