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For instance, NOX1 and NOX2 are critical for the differentiation of monocytes to macrophages and the M2-type polarization, as assessed in macrophages from NOX1/NOX2 double knockout mice ( Nox2 -deficient mice were protected against hepatic steatosis induced by high-fat diet and insulin resistance ( Finally, different studies investigated the impact of NOX in the activation of the NLRP3 inflammasome in macrophages

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6 When this happens, all the intracellular antioxidants are devoted to managing these ferrous free radicals and are often unable to keep up

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Updated March 1, 2023