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388 However, the pharmacological or genetic inhibition of GSK-3 has been shown to impair liver regeneration

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This further reduces the contact time between vitamin B12 and the areas where it would normally be absorbed

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Thus, one aspect of the invention provides an isolated nucleic acid molecule comprising, or alternatively consisting of, a polynucleotide having a nucleotide sequence selected from the group consisting of: (a) a nucleotide sequence encoding a MMP-29 related polypeptide having an amino acid sequence as shown in the sequence listing and described in SEQ ID NO:1 or the cDNA contained in ATCC deposit No:Z