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The use of citrate to buffer adalimumab solutions has also been related to a higher sensation of pain [41, 42], although given the design of some of these studies it is difficult to attribute the differences in the injection site-related pain to the content in citrate buffer

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However, it is common practice to administer hypertonic solutions to reduce the total volume injected

Except as provided in paragraphs (c)(1)(i) and (ii) of this section, the quality performance category score is calculated for a MIPS eligible clinician, group, or APM Entity group in accordance with 414.1380(b)(1) based on the quality measure set applicable to the MIPS eligible clinician, group, or APM Entity group under paragraph (c)(1)(iii) of this section and established by CMS through rulemaking for a MIPS payment year

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