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Hypersensitivity: anaphylaxis, photosensitivity, rash, urticaria, purpura, necrotizing angiitis (vasculitis, cutaneous vasculitis), fever, respiratory distress including pneumonitis

A similar vicious cycle has been implicated in the pathogenesis of DED [4, 10, 11]

These ROS activate nicotinamide adenine dinucleotide phosphate (NADPH) oxidases and inflammasomes involved in the inflammatory response, such as the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, resulting in the release of inflammatory mediators like the cytokine IL- 1

In patients with type 2 diabetes, higher PA thresholds were associated with a lower incidence of DR after adjustment for major confounders, including age, diabetes duration, HbA1c, blood pressure, and lipid profiles (247)