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Comment: A few commenters requested CMS coordinate with HRSA to prevent the duplication of 340B discounts and possibly overstated inflation rebate obligations due to 340B units not being wholly excluded

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Substituting these amino acids influenced both the catabolism [49, 52] and neonatal transcytosis [52] of mouse IgG1 fragments in wild-type (WT) mice in a manner that correlated with the binding affinity of the mutated Fc fragments towards mouse FcRn at pH 6.0 [51]

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