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Overexpression of CPT1A similarly suppressed the TGF 2 -induced upregulation of glycolysis and glycolytic capacity (Fig

ULK1 then phosphorylates both ATG13 and FIP200, triggering the recruitment of the BECLIN-1VPS34 complex to the pre-autophagosomal membrane and facilitating autophagosome formation

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Materials and Methods Test Compounds All compounds including astemizole, chlorpromazine, chloroquine, clomipramine, desipramine, fluoxetine, imipramine, nortriptyline, paroxetine, sertraline, thioridazine, dimethylsulfoxide (DMSO), bafilomycin A (BFA) and rapamycin were purchased from Sigma Aldrich (St