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We also note that the flux around the methionine cycle is 205 M/hr and approximately half enters the transsulfuration pathway (V CBS = 103 M/hr) and half is remethylated to methionine in accordance with the results of Finkelstein and Martin [22]

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In some cases, vacuolar peptidases may cleave the glutamate and glycine of the original glutathione molecule, leaving the cysteinyl conjugate (cysteine-X) which may need further processing in Phase III reactions, such as incorporation into cell wall material