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Histopathological and experimental findings suggest that structural gonadal alterations and epigenetic changes may contribute to prolonged fertility impairment

To create the glutathione model used in this paper, we took the model from [11] and added the glutathione pathway, homocysteine, cystathionine, cysteine, glutamylcysteine, GSH, and GSSG [Figure 1] from a previous model of glutathione metabolism [14]

12 In contrast, cell senescence can occur whenever under a specific stress condition, and it may also play a positive role in wound healing and tumor inhibition

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According to studies in animal models of glaucoma, the progressive RGCs death occurs mainly via apoptosis triggered by several interrelated mechanisms, including mechanical stress and impaired axonal transport of neurotrophic factors, glutamate excitotoxicity, as well as retinal ischemia and oxidative stress 8