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Circulation 135 (5), 476489

At that time Black recalls 'the immediate cause of ulceration was recognised to be hypersecretion of acid but the nature of the driving stimulus was unknown

Medrano-Fernandez, I

At first, it seemed unlikely to have screened over 3,000 analogs for ENL only to discover a compound that operates through the known effector, CRBN, and even more improbable when considering that the compound possesses minimal independent affinity for the E3 ligase