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[70] [71] Humans first cultivated grains in the Neolithic period (beginning about 9500 BCE) in the Fertile Crescent in Western Asia

One study showed that the prevalence was 62% compared to 10% in the general population

The response rate to the drug, based on HRSD 17 scores, was 69.3% after 8 weeks, compared with 30.7% who were classified as nonresponders for this study

Gene expression profiling studies, particularly the Broad Institute Connectivity Map analysis published by Pickart and colleagues, demonstrated that GHK-Cu modulates the expression of approximately 4,000 human genes, representing roughly 6% of the human genome

doi:10.1681/ASN.2012070718 7