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Abstract The heart contracts about 100,000 times a day and pumps about 7000 liters of blood into the aorta per day or about 2.6 million liters per year for a person weighing about 60 kg

Marinov has years of experience in scientific research and preventive and clinical medicine

ICAMs over-expression in endothelial cells is the initiating step for atherosclerotic plaque formation (Moss and Ramji 2016)

Plasma cell differentiation is accompanied by endoplasmic reticulum enlargement, increased membrane-bound ribosomes, upregulation of endoplasmic reticulum chaperones such as BIP and GRP94, and transcription factors like XBP-1 ( Figure 3 )

Together, these effects reduce the degree of fibrosis induced by UUO/IRI (Wang et al., 2024b)