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(2014) found that DSIP could protect neurons from oxidative stress, suggesting potential applications in the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's disease

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Within the context of the Dihexa pathway, which is studied for its ability to support synaptogenesis through HGF/c-Met signaling, having typical BDNF function suggests that the underlying neuroplasticity pathways that support synapse formation and neural network remodeling likely operate within a normal physiological range