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This kind of stress can be subtle but powerful

the deepest point is up to 29 meters

J Cancer Res

in Arzneimittelforschung (1989) Vol.39 pp177-80 Synthesis and expression in Escherichia coli of the gene encoding monocyte-derived neutrophil-activating factor: biological equivalence between natural and recombinant neutrophil-activating factor Lindley, I