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Because KAT6A contains multiple functional domains, it is possible that ARTHS variants may result in a truncated protein that retains acetyltransferase activity but lacks proteinprotein interaction domains that regulate this activity

Among the three methods mentioned, Hausdroff distance is a more reliable measure of dissimilarity in GSM models due to its interval-based representation (hence, can be used for FVA-predicted flux ranges), ability to incorporate uncertainty, and its sensitivity to the extreme values

Exosome-loaded degradable polymeric microcapsules for the treatment of vitreoretinal diseases

In contrast, the PCC group formed a distinct cluster toward the left side of the plot, indicating a proteomic signature different from both the convalescent and uninfected groups

Various stimuli, including telomere dysfunction and oxidative stress, induce cellular senescence through the p53 and Rb proteins, and senescent cells can promote disorders associated with aging or age-related diseases