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For example, we and others have found that renal cancer cells (RCC) with loss of VHL (Von Hippel-Lindau), a tumor suppressor that destabilizes HIF1A via ubiquination, are significantly sensitive to ascorbate treatment compared to VHL-proficient cells

Bulk and single-cell transcriptome profiling reveal extracellular matrix mechanical regulation of lipid metabolism reprograming through yap/tead4/acadl axis in hepatocellular carcinoma

Nevertheless, it is worth stating that the exploration of more tumor types and more comprehensive mechanisms that correlate with the gutbone axis is absolutely necessary

Young, B

By 2050, NAFLD should cause 19,300 new cases of HCC and 4,200 new cases of LT per year, a substantial increase from 10,400 and 1,700 cases in 2020, respectively