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10.1007/s00418-013-1123-8 173 ProtterD

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Without enough manganese in the body to maintain the activity of manganese superoxide dismutase, the balance between the production and breakdown of superoxide is compromised and the oxidants begin damaging cells in the liver

(E and F) Cisplatin-induced cell viability and cytotoxicity assay using calcein AM and ethidium homodimer (EthD-1) fluorescence staining with confocal microscopy (E) and flow cytometry (F)

Notably, BUD13 immunoprecipitated WT F-SNIP1 more efficiently than the F-SNIP1 mutants, indicating a reduced ability of the mutants to associate with the activated spliceosome (Fig