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Have they solved the problem purely by reference to the spatial cues, or has the physical process of "swimming in the general area until bumping into a submerged object" been a significant part of the strategy

Sharma J, Sarmah P, Bishnoi NR

Azzam EI, Jay-Gerin JP, Pain D

In recent years, IDH inhibitors targeting IDH mutants, including ivosidenib and enasidenib (Table 1), have been approved by the Food and Drug Administration to be used in patients with IDH1 or IDH2 mutant recurrent or refractory AML, respectively (Kim, 2017

Mitochondrial isolation To obtain the mitochondrial fraction, cell pellets were frozen at 80 C and homogenized (1012 strokes) in a glass-Teflon PotterElvehjem homogenizer in buffer A (83 mM sucrose and 10 mM MOPS