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A deeper understanding of how the antibody delivers its lethal hits or channels signals is also key

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While a hormetic model, low ROS promoting proliferation and high ROS inducing senescence or death, is widely reported, this framework does not consider the highly context-dependent redox fluctuations occurring under neuroinflammatory conditions (Jomova et al., 2023)

Stroke 2011;42:2672-713

Its medicinal-chemistry program, described in detail by Kruse and colleagues, introduced several deliberate substitutions into the amylin backbone: residues borrowed from rat amylin (which does not readily form fibrils) to blunt the aggregation tendency, an engineered salt bridge to stabilize the central helix, and a C 20 fatty-diacid moiety attached through a linker to promote reversible binding to serum albumin