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They are supportive, not curative

It has been demonstrated that when GS is inhibited, a variety of metabolic pathways other than glutamine synthesis are activated, thereby underscoring the remarkable plasticity of cancer cell metabolism

Finally, because this retrospective study used samples collected over multiple years, the effects of long-term storage and pre-analytical variability cannot be entirely excluded, particularly for labile lipid mediators such as eicosanoids, despite standardized processing and storage at -80 C

Nrf2 inhibition induces oxidative stress, renal inflammation and hypertension in mice

TNF-mediated tumor cell killing was shown to be reinforced by IAP antagonists (Smac mimetics) in the majority of cancer types