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Taken together, the combined burden of on-target toxicity and off-target effects constrains the therapeutic window and constitutes a practical barrier to clinical development, making it essential to pair analog optimization with delivery strategies that confine exposure to lesions and minimize unintended pathway engagement in normal tissues

Molecules 26, 1417

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Studies demonstrate that losing 710% of body weight can significantly reduce hepatic steatosis, whilst weight loss exceeding 10% may reverse NASH and improve fibrosis

And I get it, and it's hard to do, and it's confusing, but at minimal, we can follow the guidance of countries who have better health standards than the US has today