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Incidence Data emerging from randomized clinical trials (RCTs) shows that the frequency and the incidence of irAEs usually depend on the ICI agent used, duration of exposure, dose and patients risk factors profile

In humans, this becomes especially apparent as it affects their ability to adapt to complex situations where more than one cognitive process is at play

-LA, a naturally occurring dithiol with antioxidant and anti-inflammatory function, can decrease the interaction between Nrf2 and Keap1, inhibit the pro-inflammatory cytokine IL-8 production and minimize the infection via the Nrf2/HO-1 pathway in the AGS cells (161)

It prevents OS-induced death of mutant SOD1 motor neuron cells by alteration of cell survival and death signals (Koh et al., 2004)