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The role of Ido1 and tryptophan metabolism, together with arginine metabolizing enzymes, has been extensively studied in the context of metabolic reprogramming of immune cells for balancing immunoregulatory and pro-inflammatory phenotypes 157,158,159 , thus being critical to wound healing, neoplasia, autoimmunity and the rejection of transplanted tissues 155,160,161,162

Even a small improvement in the efficiency of genetic vaccine vectors to enter the cells can result in a dramatic increase in the level of immune response induced by genetic vaccination

Reinforcing previous findings 27 , our study found that L-carnitine and L-acetylcarnitine were elevated in the glaucomatous aqueous humor

The study of these distinct populations provides valuable insights into evolutionary processes, as well as metabolic and molecular adaptations to extreme environments

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