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The index is the objective remission rate of post-stratified first-line or combined treatment/progressive survival, which is significantly improved, and its repeatability has been reported ( 6.2 Accompanying the coordinated promotion of diagnosis and adaptive clinical trials Starting in phase II, a threshold-locking companion diagnostic strategy was developed in parallel, and a basket/umbrella design with a medium-term suspension rule was implemented to enable rapid validation of the metabolic target

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Subsequently, 6 M wild-type or mutant ScGrx7 was incubated for 180 s with 150 M iodacetamide at 23 C in a three-buffer system 59 containing 100 mM KCl, 50 mM potassium acetate, 50 mM MES, and 100 mM Tris at pH values between 3.5 and 8.5