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Gastrointestinal Ischemia-Reperfusion Injury Interruption of the blood supply results in ischemic injury and the damage of metabolically active tissues including the intestine [58]

& Bouchelouche, P

(D) Heatmap representation of transcriptomic profiles of Mock and MST6-I cells, either untreated or treated with secretome/CM from white or TWAT(Mock) and TWAT(MST6-I) adipocytes, related to fatty acid metabolic processes

INTRODUCTION Methotrexate (MTX) is a synthetic antimetabolite with many therapeutic indications, mainly anti-inflammatory and immunosuppressant at relatively low doses and antineoplastic at high doses.[ , ] MTX competitively inhibits dihydrofolate reductase, so decreasing tetrahydrofolate level leads to blocks the synthesis of purines, pyrimidines, DNA, ribonucleic acid, thymidylate, and proteins.[ , , ] It is well known that MTX is a hepatotoxic drug, and this leads to limitation of its clinical use

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