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This dual pro-inflammatory and pro-survival action provided a novel mechanistic explanation for the persistent inflammation observed in vitiligo lesions

RSL3 subdued DNA damage repair response by suppressing phosphorylation of nucleophosmin 1 (NPM1)

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These enzymes play key roles in glycolysis, glutaminolysis, and fatty acid oxidation

4.3.3 Cellular lipotoxicity and fatty acids One of the main initiators of macrophage foam cell development and atherosclerosis is the disturbance of regular lipid metabolism in macrophages