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Biochem Pharmacol 180:114147

Variants of MTHFR , which is a critical enzyme for intracellular folate homeostasis and metabolism, were reported to be associated with elevated circulating homocysteine levels and many diseases including PCa

Additionally, the administration of curcumin has demonstrated therapeutic potential by negatively regulating various signaling pathways (PI3/Akt, JAK/STAT, and -catenin), inhibiting the expression of COX-2, iNOS, and co-stimulatory molecules (RANKL, ICAM-1, CD205, CD256, TLR4, among others), and suppressing immune cell chemotaxis, including the infiltration of neutrophils into inflamed regions (Zhao et al., 2016

Ethics declarations Competing interests The corresponding author Guang-ji Wang is a member of the Editorial Board of the journal Acta Pharmacologica Sinica, but he has not been involved in the peer-review or decision-making process for this manuscript

Ipamorelin increases collagen production and supports healthy nails, skin, and hair