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The BBB consists of endothelial cells held by tight junctions and adherens junctions, a basement membrane that serves as a scaffold, pericytes that surround the vessels, and astrocytic end feet encircling them both (Maiuolo et al., 2018)

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In the 1920s, Otto Warburg observed for the first time that tumors consume more glucose than surrounding normal tissue, leading him to propose the phenomenon of aerobic glycolysis, wherein glucose can be fermented to produce lactate instead of carbon dioxide, even in the presence of oxygen