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Notably, -alanine and the cyclic P4S inhibitors also mimic taurine, occupying the same substrate-binding site

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METHODS We searched MEDLINE for articles pertaining to environmental risk factors in CKDu, using the search terms: Chronic kidney disease of unknown etiology, Chronic interstitial nephritis in agricultural communities, Chronic kidney disease nontraditional, Chronic renal insufficiency, uncertain etiology along with heavy metal*, fluoride, pesticide*, agrochemical*, and heat stress. Review articles, systematic and narrative reviews, and policy discussions were excluded from further analysis

Research indicates it may support collagen cross-linking and stabilization through its role as a cofactor in hydroxylation reactions

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