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This control depends on the tight modulation of the expression of genes encoding key metabolic enzymes, which includes negative feedback loops operated by their enzymatic products (Bi et al , 2018)

142 By deleting AKT1/2 or PI3KR1, FOXO expression can be disrupted, resulting in the development and maturation of B cells, particularly marginal zone B cells

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With age, NAD + levels decrease while NADH levels increase, leading to metabolic disorders, mitochondrial dysfunction, oxidative stress, and accelerated aging (137)