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Protons play a crucial role in biochemical networks because changes in intracellular pH affect cell functioning at different levels as it impacts protein folding, enzyme activities, and the protonation of biological macromolecules, lipids, and other metabolites

It is evident that the basal levels of intracellular GSSP are usually very low, being about 23 orders of magnitude lower than cytoplasmic GSH concentration (Giustarini et al

Recent research has shown that study participants on a ketogenic diet had higher vitamin C levels than participants on a moderate-carb diet, even when getting only 4% of calories from carbohydrates, making it difficult to get substantial amounts of vitamin C from nonanimal sources [18]

During preparation of this manucript, PUFA-containing plasmalogens were shown to promote ferroptosis [48], which complements our findings that alkyl chains strongly dictate sensitivity