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doi:10.7326/M14-2841

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The evidence base requires appropriate clinical trials, with additional endpoints including clinical symptoms of patients and additional biochemical parameters beyond plasma B12 levels alone before these alternative routes can be recommended with confidence in clinical guidelines

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This diversity of hit matter covering the leucine pocket and the phenylalanine pocket of the TIN2 TBM peptide will provide a firm starting point for efforts aimed at linking and merging hits

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