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Future research is also needed to explore the antidepressant effects of LAC acting as part of a system network with other important mediators of brain plasticity in comparison with classical antidepressant drugs with particular focus on the effects in specific phenotypes of depression well-characterized not only for the individual endogenous levels of LAC but also for the corresponding changes in metabolic and inflammatory pathways as well as for history of adverse childhood experiences

Numerous studies revealed that cancer is the results of oxidative DNA damage by ROS, in which hydroxylation of bases of DNA molecule take place followed by change in DNA structure

Key Takeaway: Standard oral supplements often fail because they are destroyed during digestion

5.2 Future perspectives and challenges 5.2.1 Ferroptosis-related biomarkers and early diagnosis In the early stages of OA, disturbances in iron homeostasis and increased lipid peroxidation can already be observed in cartilage and synovium