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While IGF-I remains the biomarker that best reflects endogenous GH secretion, when there is a discordancy with GH and IGF-I levels, it is important for the clinician to be mindful of the associated changes in intra-portal insulin delivery to the liver when interpreting these results in the context of health and when deciding treatment regimens in disease states

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The peptides decades of research history without emergence of serious safety signals supports cautious optimism

DATA AND SOFTWARE AVAILABILITY The RNA-Seq data obtained in this study has been uploaded to NCBI GEO datasets, under accession number GSE94395 ( The software to analyze the data is available at Supplementary Material Highlights

Each batch undergoes third-party testing for purity, identity, and heavy metals