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Preclinical trials conducted on rats demonstrate measurable improvements in transected tendon reattachment and Achilles tendon rupture models, though human clinical data remain limited

Bcl-2 / Bax ratio A molecular "survival score." Bcl-2 is an anti-apoptotic protein that protects cells from death

Shea oil (shea) - helps to rejuvenate and maintain the health of the epidermis, stimulates the synthesis of fibroblasts, has pronounced antioxidant properties, protecting cells from the effects of adverse natural conditions and free radicals

Hence, a peptide was designed by substituting the negatively charged residues D42, D48, D49, E51, E56, and D57 within the p53 TAD PEP with alanine to increase its binding affinity to FOXO4 FHD and enhance membrane penetration

Then, directional cDNA libraries were created by means of the NEBNext Ultra II Directional RNA Library Prep Kit for Illumina