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TARGETS OF PHARMACOTHERAPY IN THE MANAGEMENT OF OBESITY Novel insights provided by pathophysiology indicate the presence of a complex homeostatic system in which information about the energy reserve status and the meal quality and content is relayed from the periphery (gastrointestinal tract, pancreas, and adipose tissue) via specific orexigenic and anorexigenic peptides and hormones to the central nervous system (CNS)

The synthesis constitutes a formal total synthesis, since the research groups only prepared the known intermediate cobyric acid, whose chemical conversion to vitamin B 12 was previously reported

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doi:10.1177/02601060221144801

Check dates regularly and use the oldest stock first