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Mast cells are required for experimental oral allergen-induced diarrhea

Work using mice with targeted deletion of the SEPP1 gene has shown that this protein is involved in supplying selenium to the brain and testes, results in marked decreases in testes selenium even in mice supplemented with normally adequate levels of selenium (20, 21), and results in sperm defects indistinguishable from those elicited by dietary selenium deficiency (22, 23)