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This occurs through two mechanisms: a reduction in NO production by NOS and the sequestration of NO by haem, due to its high-affinity interaction with iron (11, 2227)

These stimuli will also stimulate brain microglia and trigger the NLRP3 inflammasome to release IL-1 and IL-18 (Troubat et al., 2021)

Remarkably, another shift in the AR cistrome was observed between ADT-naive primary CaP and CRPC, with another increase in AR binding sites after ADT resistance [58, 59]

BS was also associated with a lower incidence of microvascular and all-cause mortality

For most people, this is impractical and increases the risk of dosing errors