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Description

Enjoji, M., Yasutake, K., Kohjima, M

Analyzed the data: YZ, XC, LL, ZY, and PC

Bishayee, D

doi: 10.1530/REP-13-0594

IDO inhibits the function of immune cells through a specific L-Trp depletion pathway, where L-Trp depletion by IDO leads to its dissociation with L-Trp tRNA, thus activating general control non-derepressible 2 (GCN2) due to the presence of its allosteric regulatory site which senses free tRNAs (47, 48)