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Further reduction at nitrogen 5 yields THF, the active form of the vitamin that functions as a coenzyme (Fig

(2017) conducted a randomized, double-blind, placebo-controlled crossover trial in 40 healthy adults, showing that 15 mg/day HTY for 3 weeks significantly increased plasma thiols, total antioxidant status, and SOD1 expression while reducing nitrite, nitrate, and MDA, and modestly lowering body fat mass, supporting HTYs anti-atherosclerotic and cardioprotective potential via improved redox balance and gene expression modulation [77]

Therefore, these results support that reductive stress induced by high NADH/NAD + impairs mitochondrial function and energy metabolism in the heart

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