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In conclusion, the rapid evolution and prevalence of the Omicron variant, followed by the subvariants, with greater potential for immune escape, have posed the challenge of updating the current vaccines with the S protein of emergent VOCs

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Reconstituted stability varies between peptides

The presence of a vial and the need to reconstitute do not indicate that injection is the validated cosmetic route

Bronson at the Rodent Histopathology Core at Harvard Medical School, the NextGen Sequencing Core at Massachusetts General Hospital, Center for Innovative Biomedical Resources at the University of Maryland School of Medicine and Greenebaum Comprehensive Cancer Center, the Massachusetts General Hospital Translational Imaging Core for their technical expertise