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Finally, immunohistochemistry analysis of EGFR and pEGFR in placental tissues showed a marked increase in both expression and phosphorylation of EGFR in the sRUPP group compared to the Sham group (Supplementary Fig

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Cluster 0 CAFs dominate in DTP models (59% prevalence), secreting IL- 6/TNFSF9/FGF7 to activate STAT3-mediated survival pathways while producing CCL11/CXCL1/CXCL12 to modulate immune evasion [88, 142] (Fig