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Conclusions Acidosis alters the cellular metabolism of several major metabolites, which induces a significant degree of metabolic inflexibility

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Mentula S, Harmoinen J, Heikkil M, Westermarck E, Rautio M, Huovinen P, et al

The enhanced efflux of GSSG seems to be one of the reasons, as according to Srivastava and Beutler (21) human erythrocytes transport GSSG at high levels of intracellular GSSG and red blood cell membranes transport GSSG but not GSH