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Innovative therapeutic strategies, including microbial therapeutics (such as probiotics, prebiotics, and synbiotics), natural products (such as neohesperidin, isoquercitrin, and polysaccharides), and fecal microbiota transplantation, have been proposed to restore microbial balance and improve kidney function

Hormone-based drugs are also under investigation, including those routinely used in gynaecology (10), such as GnRH antagonists, like elagolix or ganirelix

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Coating with surfactants Coating nanoparticles with a surfactant was the first method used to enhance their BBB permeation ability

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