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Future efforts should utilize in vitro dynamic models (such as the hollow-fiber infection model) and animal models to comprehensively understand the PK/PD properties of drugs, thereby enabling dosing regimens that provide maximal synergy while minimizing toxicity and resistance development (Wale et al., 2024)

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In spontaneously hypertensive rats, NW up-regulated CSE expression in the aorta, increased H 2 S production, and alleviated hypertension, vascular remodeling, and inflammation

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