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This adaptive response is ancient biology working against modern goals

High drug exposure leads to an increased risk of sinusoidal obstruction syndrome (SOS, an early complication of hematopoietic stem cell transplantation), whereas low drug exposure has been associated with a higher risk of disease recurrence and graft failure ( The aim of our study was therefore to identity gene polymorphisms involved in the metabolism of Cy and other drugs and correlate them with complications (GVHD, SOS, HC and TRM), after Haplo-HSCT

Total observed flux can also be shaped by fatty acid delivery, albumin binding, acyl-CoA synthetase activity, CACT transport, CPT2 activity, -oxidation enzyme capacity, TCA cycle activity, electron transport chain function, mitochondrial coupling, and cell viability